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KMID : 1134820000290030506
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 3 p.506 ~ p.512
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Stability in Effects of γ - Irradiated Chinese Medicinal Prescriptions on Protection of Mice from Radiation
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Yang Jung-A
Kim Seong-Ho
Kim Se-Ra
Yu Young-Bub
Jo Sung-Kee
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Abstract
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The radioprotective effects of irradiated medicinal plants on biological system were studied to apply the irradiation technology for hygienic purpose that is usually performed by chemical preservatives. We previously reported that the three Chinese medicinal prescriptions, Si-Wu-Tang, Bu-Zhong-Yi-Qi- Tang and San-Ling-Bai-Shu-San, showed radioprotective effects in mice. In these experiments, to investigate the difference in radioprotective effects between irradiated (10 kGy) and non-irradiated me- dicinal plants, mice were administered with the irradiated or non-irradiated prescriptions and then the mice were exposed to γ-rays with low and high dosage. Non-exposed mice were also prepared as a control. The effects of prescriptions on the jejunal crypt survival, endogenous spleen colony formation, and apoptosis of jejunal crypt cells in mice were investigated after exposure. All of the prescriptions showed the protective effects of the jejunal crypt (p<0.05) and the adminstration of the prescriptions increased the formation of endogenous spleen colony (p<0.05) and reduced the frequency of radiation- induced apoptosis (p<0.05). No significant difference in effects between irradiated and non-irradiated prescription on the parameters was found in mice administered with each prescription before exposure to γ-rays. In non-exposed mice, there were no different findings in the parameters between irradiated and non-irradiated prescription. These results suggest that there should be no difference in the biological effects between irradiated and non-irradiated medicinal plants. The results may also conform a basic evidence that the irradiated medicinal plants do not affect on the biological system of the mice.
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KEYWORD
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Chinese medical prescriptions, irradiation, jejunal crypt, spleen
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